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A 1536-Well Quantitative High-Throughput Screen to Identify Compounds Targeting Cancer Stem Cells

28 Aug 2012

Abstract excerpt

Tumor cell subpopulations called cancer stem cells (CSCs) or tumor-initiating cells (TICs) have self-renewal potential and are thought to drive metastasis and tumor formation. Data suggest that these cells are resistant to current chemotherapy and radiation therapy treatments, leading to cancer recurrence. Therefore, finding new drugs and/or drug combinations that cause death of both the differentiated tumor...

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PMID: 22927676
DOI: 10.1177/1087057112458152

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