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CSN6–TRIM21 axis instigates cancer stemness during tumorigenesis

29 Mar 2020

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS: The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evaluated by organoid formation and limited dilution analysis. The role of CSN6-TRIM21-OCT1-ALDH1A1...

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PMID: 32225170
DOI: 10.1038/s41416-020-0779-9

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