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Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway

1 Dec 2019

Abstract excerpt

Abstract Background Liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) development, metastasis, and drug resistance. MSI2 and Notch1 signaling are involved in the maintenance of CSCs. However, it is unknown whether MSI2 and Notch1 are involved in the maintenance of CD44v6+ LCSCs. Therefore, we investigated the clinical significance and function of MSI2 and its relationship with Notch1...

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PMID: 31888685
DOI: 10.1186/s13046-019-1508-1

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