Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression.

doi:10.1158/1078-0432.CCR-19-3283

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Article

Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2020

Marcon Julian, DiNatale Renzo G, Sanchez Alejandro, Kotecha Ritesh R, Gupta Sounak, Kuo Fengshen, Makarov Vladimir, Sandhu Amar, Mano Roy, Silagy Andrew W, Blum Kyle A, Nassau Daniel E, Benfante Nicole E, Ortiz Michael V, Carlo Maria I, Chan Timothy A, Motzer Robert J, Voss Martin H, Coleman Jonathan, Russo Paul, Reuter Victor, Hakimi A Ari, Reznik Ed

Abstract excerpt

PURPOSE: Translocation renal cell carcinoma (tRCC) is a rare, aggressive renal cell carcinoma (RCC) subtype. There is currently limited understanding on the role of molecular alterations in the pathogenesis and progression of these tumors. We investigated the association between somatic alterations and clinical outcomes in two independent cohorts profiled using DNA sequencing. EXPERIMENTAL DESIGN: Twenty-two...

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PMID: 32220885
DOI: 10.1158/1078-0432.CCR-19-3283
PMCID: PMC7367714

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