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Article

Heterologous Expression of a VioA Variant Activates Cryptic Compounds in a Marine-Derived Brevibacterium Strain.

Marine drugs - 2 Jun 2018

Han Xiao, Hou Lukuan, Hou Jing, Zhang Yongyu, Li Huayue, Li Wenli

Abstract excerpt

A new 14-membered homodimeric macrodiolide, brevidiolide (3), along with four known aromatic compounds (1, 2, 4 and 5) were obtained by heterologous expression of the recombinant plasmid pWLI823 expressing the G231L variant of VioA in the marine-derived Brevibacterium sp. 7002-073. The structures of 1⁻5 were elucidated on the basis of LC-MS and 2D NMR spectroscopic analyses. In the evaluation for the...

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Identifiers

PMID: 29865236
DOI: 10.3390/md16060191
PMCID: PMC6024985

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