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Article

Two Lineages of KLRA with Contrasting Transcription Patterns Have Been Conserved at a Single Locus during Ruminant Speciation.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2020

Gibson Mark S, Allan Alasdair J, Sanderson Nicholas D, Birch James, Gubbins Simon, Ellis Shirley A, Hammond John A

Abstract excerpt

Cattle possess the most diverse repertoire of NK cell receptor genes among all mammals studied to date. Killer cell receptor genes encoded within the NK complex and killer cell Ig-like receptor genes encoded within the leukocyte receptor complex have both been expanded and diversified. Our previous studies identified two divergent and polymorphic KLRA alleles within the NK complex in the Holstein-Friesian breed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32213565
DOI: 10.4049/jimmunol.1801363
PMCID: PMC7167460

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