Article
Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.
Acta neuropsychiatrica - 1 Aug 2020
Yapici-Eser Hale, Appadurai Vivek, Eren Candan Yasemin, Yazici Dilek, Chen Chia-Yen, Öngür Dost, Pizzagalli Diego A, Werge Thomas, Hall Mei-Hua
Abstract excerpt
BACKGROUND: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis....
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