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GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents

2025-10-24

Abstract excerpt

<h4>Background: </h4> GLP‑1 receptor agonists (GLP‑1RAs) are effective for type 2 diabetes and obesity and engage central stress and reward pathways (HPA axis; mesolimbic dopamine). Psychiatric signals have been reported in some settings. Objective :To narratively synthesize evidence on neuropsychiatric effects of GLP‑1RAs—mood, anxiety, suicidality, reward processing, substance use, and migraine—and to consider g...

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Literature Corpus work
155baa9b-790f-52e5-9e4b-7932ad29741b
DOI
10.20944/preprints202510.1849.v1
Open publication

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