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Article

Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.

Biology open - 7 May 2020

Weber Thomas, Schlotawa Lars, Dosch Roland, Hamilton Noémie, Kaiser Jens, Schiller Stina, Wenske Britta, Gärtner Jutta, Henneke Marco

Abstract excerpt

Human infantile-onset RNASET2-deficient cystic leukoencephalopathy is a Mendelian mimic of in utero cytomegalovirus brain infection with prenatally developing inflammatory brain lesions. We used an RNASET2-deficient zebrafish model to elucidate the underlying disease mechanisms. Mutant and wild-type zebrafish larvae brain development between 2 and 5 days post fertilization (dpf) was examined by confocal live...

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Identifiers

PMID: 32295832
DOI: 10.1242/bio.049239
PMCID: PMC7225086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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