Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes.

Frontiers in immunology - 1 Jan 2020

Sohrabi Yahya, Sonntag Glenn V H, Braun Laura C, Lagache Sina M M, Liebmann Marie, Klotz Luisa, Godfrey Rinesh, Kahles Florian, Waltenberger Johannes, Findeisen Hannes M

Abstract excerpt

Objectives: The concept of trained innate immunity describes a long-term proinflammatory memory in innate immune cells. Trained innate immunity is regulated through reprogramming of cellular metabolic pathways including cholesterol and fatty acid synthesis. Here, we have analyzed the role of Liver X Receptor (LXR), a key regulator of cholesterol and fatty acid homeostasis, in trained innate immunity. Methods and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyl Coenzyme A
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Interleukin-1beta

Share to Liver X Receptors

Share to Mevalonic Acid

Share to Monocytes

Share to Mycobacterium bovis

Source

Open in PubMed Open full text

Identifiers

PMID: 32210962
DOI: 10.3389/fimmu.2020.00353
PMCID: PMC7077358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes.PMID 32210962Read ↗

Fatty acid desaturation and lipoxygenase pathways support trained immunitySemantic proximity Read ↗

The causes and consequences of trained immunity in myeloid cellsSemantic proximity Read ↗

The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory DisordersSemantic proximity Read ↗

Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitroSemantic proximity Read ↗

COVID-19 inactivated and non-replicating viral vector vaccines induce regulatory training phenotype in human monocytes under epigenetic control.Semantic proximity Read ↗

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein.Semantic proximity Read ↗

OxLDL-mediated immunologic memory in endothelial cells.Semantic proximity Read ↗

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.Semantic proximity Read ↗

Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes.Semantic proximity Read ↗

Interleukin-10 inhibits important components of trained immunity in human monocytesSemantic proximity Read ↗

Trained immunity in human monocyte enhances myeloid-T-cell pathogenic crosstalk in Ankylosing SpondylitisSemantic proximity Read ↗

Trained immunity as a novel therapeutic strategySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.