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Article

Toward a Unified Theory of Aging and Regeneration

28 Aug 2019

Abstract excerpt

Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic-fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However,...

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PMID: 31455183
DOI: 10.2217/rme-2019-0062

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