Article
Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
British journal of cancer - 1 Aug 2023
Dimou Niki, Kim Andre E, Flanagan Orlagh, Murphy Neil, Diez-Obrero Virginia, Shcherbina Anna, Aglago Elom K, Bouras Emmanouil, Campbell Peter T, Casey Graham, Gallinger Steven, Gruber Stephen B, Jenkins Mark A, Lin Yi, Moreno Victor, Ruiz-Narvaez Edward, Stern Mariana C, Tian Yu, Tsilidis Kostas K, Arndt Volker, Barry Elizabeth L, Baurley James W, Berndt Sonja I, Bézieau Stéphane, Bien Stephanie A, Bishop D Timothy, Brenner Hermann, Budiarto Arif, Carreras-Torres Robert, Cenggoro Tjeng Wawan, Chan Andrew T, Chang-Claude Jenny, Chanock Stephen J, Chen Xuechen, Conti David V, Dampier Christopher H, Devall Matthew, Drew David A, Figueiredo Jane C, Giles Graham G, Gsur Andrea, Harrison Tabitha A, Hidaka Akihisa, Hoffmeister Michael, Huyghe Jeroen R, Jordahl Kristina, Kawaguchi Eric, Keku Temitope O, Larsson Susanna C, Le Marchand Loic, Lewinger Juan Pablo, Li Li, Mahesworo Bharuno, Morrison John, Newcomb Polly A, Newton Christina C, Obon-Santacana Mireia, Ose Jennifer, Pai Rish K, Palmer Julie R, Papadimitriou Nikos, Pardamean Bens, Peoples Anita R, Pharoah Paul D P, Platz Elizabeth A, Potter John D, Rennert Gad, Scacheri Peter C, Schoen Robert E, Su Yu-Ru, Tangen Catherine M, Thibodeau Stephen N, Thomas Duncan C, Ulrich Cornelia M, Um Caroline Y, van Duijnhoven Franzel J B, Visvanathan Kala, Vodicka Pavel, Vodickova Ludmila, White Emily, Wolk Alicja, Woods Michael O, Qu Conghui, Kundaje Anshul, Hsu Li, Gauderman W James, Gunter Marc J, Peters Ulrike
Abstract excerpt
BACKGROUND: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. METHODS: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer...
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