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Article

Brain Correlates of the Interaction Between 5-HTTLPR and Psychosocial Stress Mediating Attention Deficit Hyperactivity Disorder Severity.

The American journal of psychiatry - 1 Aug 2015

van der Meer Dennis, Hoekstra Pieter J, Zwiers Marcel, Mennes Maarten, Schweren Lizanne J, Franke Barbara, Heslenfeld Dirk J, Oosterlaan Jaap, Faraone Stephen V, Buitelaar Jan K, Hartman Catharina A

Abstract excerpt

OBJECTIVE: The serotonin transporter 5-HTTLPR genotype has been found to moderate the effect of stress on severity of attention deficit hyperactivity disorder (ADHD), with stronger effects of stress in carriers of the short allele than in individuals homozygous for the long allele. The underlying neurobiological mechanism of this gene-environment interaction in ADHD is unknown. The authors aimed to determine...

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PMID: 25998280
DOI: 10.1176/appi.ajp.2015.14081035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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