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Article

Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide.

Protein science : a publication of the Protein Society - 1 Oct 2009

Alag Reema, Bharatham Nagakumar, Dong Aiping, Hills Tanya, Harikishore Amaravadhi, Widjaja Anissa Anindya, Shochat Susana Geifman, Hui Raymond, Yoon Ho Sup

Abstract excerpt

Plasmodium falciparum FK506-binding protein 35 (PfFKBP35) that binds to FK506 contains a conserved tetratricopeptide repeat (TPR) domain. Several known TPR domains such as Hop, PPP5, CHIP, and FKBP52 are structurally conserved and are able to interact with molecular chaperones such as Hsp70/Hsp90. Here, we present the crystal structure of PfFKBP35-TPR and demonstrate its interaction with Hsp90 C-terminal...

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Identifiers

PMID: 19691130
DOI: 10.1002/pro.226
PMCID: PMC2786975

Genes

TPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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