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Impaired Fertility and FSH Synthesis in Gonadotrope-Specific Foxl2 Knockout Mice

23 Jan 2013

Abstract excerpt

Impairments in pituitary FSH synthesis or action cause infertility. However, causes of FSH dysregulation are poorly described, in part because of our incomplete understanding of mechanisms controlling FSH synthesis. Previously, we discovered a critical role for forkhead protein L2 (FOXL2) in activin-stimulated FSH β-subunit (Fshb) transcription in immortalized cells in vitro. Here, we tested the hypothesis that...

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PMID: 23340250
DOI: 10.1210/me.2012-1286

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