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Article

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats.

Scientific reports - 18 Mar 2020

Asano Ryutaro, Hosokawa Katsuhiro, Taki Shintaro, Konno Shota, Shimomura Ippei, Ogata Hiromi, Okada Mai, Arai Kyoko, Onitsuka Masayoshi, Omasa Takeshi, Nakanishi Takeshi, Umetsu Mitsuo, Kumagai Izumi

Abstract excerpt

Designing non-natural antibody formats is a practical method for developing highly functional next-generation antibody drugs, particularly for improving the therapeutic efficacy of cancer treatments. One approach is constructing bispecific antibodies (bsAbs). We previously reported a functional humanized bispecific diabody (bsDb) that targeted epidermal growth factor receptor and CD3 (hEx3-Db). We enhanced its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32188928
DOI: 10.1038/s41598-020-61840-3
PMCID: PMC7080790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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