Article
Comprehensive study of domain rearrangements of single-chain bispecific antibodies to determine the best combination of configurations and microbial host cells.
mAbs - 1 Jan 2000
Asano Ryutaro, Kuroki Yuri, Honma Sachiko, Akabane Mihoko, Watanabe Shunsuke, Mayuzumi Shinzo, Hiyamuta Shuichi, Kumagai Izumi, Sode Koji
Abstract excerpt
Small bispecific antibodies (bsAbs) are important therapeutic molecules and represent the first bsAb format approved by the United States Food and Drug Administration. Diabody (Db), a small bsAb format, has four possible domain orders; we previously reported the differences in the expression levels and cancer growth inhibition effects upon rearranging the domain order of this format. However, there have been no...
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