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Article

Global Genetic Variation in Circulating 25-Hydroxyvitamin D: A Systematic Review of GWAS Evidence Across Different Ancestral Groups.

Nutrients - 24 Jun 2026

Papoutsis Alexandros, Malikides Danae, Georgiou Andrea, Lamnisos Demetris, Heraclides Alexandros

Abstract excerpt

BACKGROUND/OBJECTIVES: Vitamin D deficiency is a global health concern, yet circulating 25-hydroxyvitamin D (25OHD) concentrations vary substantially across geographical regions and ancestral groups. Genetic predisposition may contribute to these differences. This systematic review aimed to synthesize evidence from genome-wide association studies (GWAS) on genetic variation associated with circulating 25OHD...

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Share to DHCR7 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 42451056
DOI: 10.3390/nu18132052
PMCID: PMC13363548

Genes

CYP2R1
DHCR7
FLG
GC
NADSYN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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Global Genetic Variation in Circulating 25-Hydroxyvitamin D: A Systematic Review of GWAS Evidence Across Different Ancestral Groups.PMID 42451056Read ↗

Genome-wide association study of circulating vitamin D levels.Semantic proximity Read ↗

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.Semantic proximity Read ↗

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Common genetic determinants of vitamin D insufficiency: a genome-wide association study.Semantic proximity Read ↗

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Common Genetic Determinants of Vitamin D Insufficiency: A Genome-Wide Association StudySemantic proximity Read ↗

Genome-wide association study (GWAS) of circulating vitamin D outcomes among individuals of African ancestry.Semantic proximity Read ↗

Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D.Semantic proximity Read ↗

Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans.Semantic proximity Read ↗

Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans.Semantic proximity Read ↗

Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populationsSemantic proximity Read ↗

Integrative Analysis of Vitamin D-Associated Genetic Variants Reveals Cis-Regulatory Architecture and Multigenic Mechanisms Underlying Chronic Disease-Relevant Pathways.Semantic proximity Read ↗

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