Article
Mutation and recombination in pathogen evolution: Relevance, methods and controversies.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2018
Arenas Miguel, Araujo Natalia M, Branco Catarina, Castelhano Nadine, Castro-Nallar Eduardo, Pérez-Losada Marcos
Abstract excerpt
Mutation and recombination drive the evolution of most pathogens by generating the genetic variants upon which selection operates. Those variants can, for example, confer resistance to host immune systems and drug therapies or lead to epidemic outbreaks. Given their importance, diverse evolutionary studies have investigated the abundance and consequences of mutation and recombination in pathogen populations....
Topics
- Antiviral Agents
- Biological Evolution
- Computational Biology
- Drug Resistance, Viral
- Genetic Fitness
- HIV Infections
- HIV-1
- Hepatitis B
- Hepatitis B virus
- Host-Pathogen Interactions