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Article

CYLD variants identified in Alzheimer's disease and frontotemporal dementia patients.

Annals of clinical and translational neurology - 1 Oct 2022

Xiao Xuewen, Xu Tianyan, Liu Hui, Liu Xixi, Liao Xinxin, Zhou Yafang, Zhou Lu, Wang Xin, Zhu Yuan, Yang Qijie, Hao Xiaoli, Liu Yingzi, Jiang Hong, Guo Jifeng, Wang Junling, Tang Beisha, Li Jinchen, Shen Lu, Jiao Bin

Abstract excerpt

OBJECTIVES: CYLD was a novel causative gene for frontotemporal dementia (FTD) and amyotrophic lateral sclerosis. Given the clinical and pathological overlap of FTD and Alzheimer's disease (AD), it is necessary to screen CYLD in AD patients and FTD patients in the Chinese population. METHODS: In our study, using a targeted sequencing panel, we sequenced the CYLD gene in a large cohort of 2485 participants in the...

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PMID: 36000313
DOI: 10.1002/acn3.51655
PMCID: PMC9539372

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