Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans.

doi:10.1172/jci.insight.136136

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Article

Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans.

JCI insight - 9 Apr 2020

Laurenti Marcello C, Dalla Man Chiara, Varghese Ron T, Andrews James C, Rizza Robert A, Matveyenko Aleksey, De Nicolao Giuseppe, Cobelli Claudio, Vella Adrian

Abstract excerpt

BACKGROUNDMetabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously associated with β cell dysfunction, would be associated with changes in these insulin pulse characteristics.METHODSTwenty-nine nondiabetic subjects (age 46 ± 2, BMI 28 ± 1 kg/m2) participated in this study. Of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 2

Share to Insulin-Secreting Cells

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Share to Polymorphism, Genetic

Share to Transcription Factor 7-Like 2 Protein

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Identifiers

PMID: 32182220
DOI: 10.1172/jci.insight.136136
PMCID: PMC7205281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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