Article

B cells imprint adoptively transferred CD8 <sup>+</sup> T cells with enhanced tumor immunity

2021-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Here we report a novel strategy to reverse the tolerant state of adoptively transferred CD8 + T cells against melanoma through ex vivo expansion with the TLR9 agonist CpG. T cells generated in the presence of CpG display potent anti-tumor efficacy without in vivo co-administration of high dose IL-2 or vaccination, which are classically required for effective treatment of solid tumors using ad...

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Literature Corpus work: 6d8292f7-4d44-5806-8a39-7914d8985549
DOI: 10.1101/2021.03.16.435714

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