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Article

Immune Profiling of Deficient Mismatch Repair Colorectal Cancer Tumor Microenvironment Reveals Different Levels of Immune System Activation.

The Journal of molecular diagnostics : JMD - 1 May 2020

Giannini Riccardo, Zucchelli Gemma, Giordano Mirella, Ugolini Clara, Moretto Roberto, Ambryszewska Katarzyna, Leonardi Michele, Sensi Elisa, Morano Federica, Pietrantonio Filippo, Cremolini Chiara, Falcone Alfredo, Fontanini Gabriella

Abstract excerpt

To understand the immune landscape of deficient mismatch repair colorectal cancer (dMMR CRC) tumor microenvironment, gene expression profiling was performed by the nCounter PanCancer Immune Profiling Panel. This study was conducted retrospectively on 89 dMMR-CRC samples. The expression of CD3, CD8, programmed death-1, and programmed death ligand-1 protein was evaluated on a subset of samples by...

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PMID: 32173570
DOI: 10.1016/j.jmoldx.2020.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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