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Article

Cryptic aberrations may allow more accurate prognostic classification of patients with myelodysplastic syndromes and clonal evolution.

Genes, chromosomes & cancer - 1 Jul 2020

Svobodova Karla, Lhotska Halka, Hodanova Lucie, Pavlistova Lenka, Vesela Denisa, Belickova Monika, Vesela Jitka, Brezinova Jana, Sarova Iveta, Izakova Silvia, Lizcova Libuse, Siskova Magda, Jonasova Anna, Cermak Jaroslav, Michalova Kyra, Zemanova Zuzana

Abstract excerpt

The karyotype of bone-marrow cells at the time of diagnosis is one of the most important prognostic factors in patients with myelodysplastic syndromes (MDS). In some cases, the acquisition of additional genetic aberrations (clonal evolution [CE]) associated with clinical progression may occur during the disease. We analyzed a cohort of 469 MDS patients using a combination of molecular cytogenomic methods to...

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Identifiers

PMID: 32170980
DOI: 10.1002/gcc.22841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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