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Article

A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2014

Church Rachel J, Wu Hong, Mosedale Merrie, Sumner Susan J, Pathmasiri Wimal, Kurtz Catherine L, Pletcher Mathew T, Eaddy John S, Pandher Karamjeet, Singer Monica, Batheja Ameesha, Watkins Paul B, Adkins Karissa, Harrill Alison H

Abstract excerpt

Isoniazid (INH), the mainstay therapeutic for tuberculosis infection, has been associated with rare but serious hepatotoxicity in the clinic. However, the mechanisms underlying inter-individual variability in the response to this drug have remained elusive. A genetically diverse mouse population model in combination with a systems biology approach was utilized to identify transcriptional changes, INH-responsive...

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Identifiers

PMID: 24848797
DOI: 10.1093/toxsci/kfu094
PMCID: PMC4168290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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