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Article

Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice.

Toxicology - 1 Sept 2021

Mosedale Merrie, Cai Yanwei, Eaddy J Scott, Kirby Patrick J, Wolenski Francis S, Dragan Yvonne, Valdar William

Abstract excerpt

Development of TAK-875 was discontinued when a small number of serious drug-induced liver injury (DILI) cases were observed in Phase 3 clinical trials. Subsequent studies have identified hepatocellular oxidative stress, mitochondrial dysfunction, altered bile acid homeostasis, and immune response as mechanisms of TAK-875 DILI and the contribution of genetic risk factors in oxidative response and mitochondrial...

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Identifiers

PMID: 34418498
DOI: 10.1016/j.tox.2021.152902
PMCID: PMC8936092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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