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Article

Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation

28 Nov 2005

Abstract excerpt

The cellular polypyrimidine tract-binding protein (PTB) is recruited by the genomic RNAs of picornaviruses to stimulate translation initiation at their internal ribosome entry site (IRES) elements. We investigated the contribution of the individual RNA recognition motif (RRM) domains of PTB to its interaction with the IRES of foot-and-mouth disease virus (FMDV). Using a native gel system, we found that PTB is a...

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PMID: 16314455
DOI: 10.1261/rna.7430405

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Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translationPMID 16314455Read ↗

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