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Article

Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.

Diabetes - 1 Jun 2020

Sharma Isha, Deng Fei, Liao Yingjun, Kanwar Yashpal S

Abstract excerpt

Conceivably, upregulation of myo-inositol oxygenase (MIOX) is associated with altered cellular redox. Its promoter includes oxidant-response elements, and we also discovered binding sites for XBP1, a transcription factor of endoplasmic reticulum (ER) stress response. Previous studies indicate that MIOX's upregulation in acute tubular injury is mediated by oxidant and ER stress. Here, we investigated whether...

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Share to Blood Glucose
Share to Diabetes Mellitus, Experimental
Share to Diabetic Nephropathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Chaperone BiP

Share to Gene Expression Regulation, Enzymologic

Share to Hyperglycemia

Share to Insulin

Share to Reactive Oxygen Species

Source

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Identifiers

PMID: 32169892
DOI: 10.2337/db19-0935
PMCID: PMC7243294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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