Article
Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
Journal of diabetes and its complications - 1 Jan 2000
Yang Bingmei, Hodgkinson Andrea, Millward Beverley A, Demaine Andrew G
Abstract excerpt
Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. The increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the MI depletion found in the diabetic complications. The aim was to investigate whether single nucleotide polymorphisms (SNPs) in the MIOX gene are associated with Type 1 diabetes mellitus...
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