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Article

Imaging GPCR internalization using near-infrared Nebraska red-based reagents.

Organic & biomolecular chemistry - 1 Apr 2020

Lesiak Lauren, Zhou Xinqi, Fang Yuan, Zhao Jia, Beck Jon R, Stains Cliff I

Abstract excerpt

Internalization of G protein-coupled receptor (GPCRs) represents a nearly universal pathway for receptor downregulation. Imaging this process provides a means for the identification of pharmaceutical agents as well as potential ligands for orphan receptors. However, there is a need for the further development of near-infrared (NIR) probes capable of monitoring internalization in order to enable multiplexing with...

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Identifiers

PMID: 32167123
DOI: 10.1039/d0ob00043d
PMCID: PMC7261517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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