Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

Abstract excerpt

The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo . However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their specific molecular targets in vivo . This is a particular problem for assessing the therapeutic potential of drugs that target malignant tumors where access and binding may...