Article
Chromosomal Substitution Strategies to Localize Genomic Regions Related to Complex Traits.
Comprehensive Physiology - 12 Mar 2020
Cowley Allen W, Dwinell Melinda R
Abstract excerpt
Chromosomal substitution strategies provide a powerful tool to anonymously reveal the relationship between DNA sequence variants and a normal or disease phenotype of interest. Even in this age of CRISPR-Cas9 genome engineering, the knockdown or overexpression of a gene provides relevant information to our understanding of complex disease only when a close association of an allelic variant with the phenotype has...
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