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Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation

30 May 2022

Abstract excerpt

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore (MPTP) which plays a key role in both cell physiology and pathology. It is, therefore, beneficial for cells to tightly regulate CypD and MPTP but little is known about such regulation. We have reported before that CypD is downregulated and MPTP deactivated during differentiation in various tissues. Herein, we identify BMP/Smad...

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PMID: 35635445
DOI: 10.7554/elife.75023

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