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Article

Role of the Polarity Protein Scribble for Podocyte Differentiation and Maintenance

7 May 2012

Abstract excerpt

The kidney filter represents a unique assembly of podocyte epithelial cells that tightly enwrap the glomerular capillaries with their complex foot process network. While deficiency of the polarity proteins Crumbs and aPKC result in impaired podocyte foot process architecture, the function of basolateral polarity proteins for podocyte differentiation and maintenance remained unclear. Here we report, that Scribble...

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Identifiers

PMID: 22586490
DOI: 10.1371/journal.pone.0036705

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