Article
The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis.
Atherosclerosis - 1 May 2020
Bruikman Caroline S, Vreeken Dianne, Zhang Huayu, van Gils Marit J, Peter Jorge, van Zonneveld Anton Jan, Hovingh G Kees, van Gils Janine M
Abstract excerpt
BACKGROUND AND AIMS: Neuroimmune guidance cues have been shown to play a role in atherosclerosis, but their exact role in human pathophysiology is largely unknown. In the current study, we investigated the role of a c.1769G > T variant in Netrin-1 in (premature) atherosclerosis. METHODS: To determine the effect of the genetic variation, purified Netrin-1, either wild type (wtNetrin-1) or the patient observed...
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