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Article

Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia.

Science advances - 22 Sept 2023

Robinson Troy M, Bowman Robert L, Persaud Sonali, Liu Ying, Neigenfind Rosemary, Gao Qi, Zhang Jingping, Sun Xiaotian, Miles Linde A, Cai Sheng F, Sciambi Adam, Llanso Aaron, Famulare Christopher, Goldberg Aaron, Dogan Ahmet, Roshal Mikhail, Levine Ross L, Xiao Wenbin

Abstract excerpt

Measurable residual disease (MRD), defined as the population of cancer cells that persist following therapy, serves as the critical reservoir for disease relapse in acute myeloid leukemia and other malignancies. Understanding the biology enabling MRD clones to resist therapy is necessary to guide the development of more effective curative treatments. Discriminating between residual leukemic clones, preleukemic...

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Identifiers

PMID: 37729414
DOI: 10.1126/sciadv.adg0488
PMCID: PMC10881057

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