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A Kidney Stone–Associated CLDN4 Variant Impairs Tight Junction Stability and Paracellular Ion Permeability

2026-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Claudin-4 (CLDN4) is a key determinant of paracellular ion transport in the distal nephron, where it contributes to chloride permeability and transepithelial resistance. Although CLDN4 knockout mice exhibit hypercalciuria, the epithelial mechanism linking CLDN4 to calcium permeability and kidney stone disease remains unclear. We examined the molecular and functional effects of a kidney stone–ass...

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Literature Corpus work
218a2c0f-3a3d-50fa-98eb-bccc5aa25c29
DOI
10.64898/2026.02.10.705174
Open publication

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A Kidney Stone–Associated CLDN4 Variant Impairs Tight Junction Stability and Paracellular Ion PermeabilityDOI 10.64898/2026.02.10.705174
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