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Article

A lipase fusion feasts on fat.

The Journal of biological chemistry - 6 Mar 2020

Ruppert Philip M M, Kersten Sander

Abstract excerpt

The enzyme lipoprotein lipase (LPL) is responsible for breaking down triglycerides in the blood. Mutations in LPL cause a rare but debilitating disorder characterized by excessive plasma triglyceride levels for which treatment options are limited. Nimonkar et al. now present a fusion protein between LPL and its physiological transporter GBIHBP1 that is highly active and largely resistant to physiological...

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Identifiers

PMID: 32144145
DOI: 10.1074/jbc.H120.012744
PMCID: PMC7062189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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