Article

A VLP-based vaccine targeting ANGPTL3 lowers plasma triglycerides in mice

2021-03-08

Abstract excerpt

Elevated triglycerides (TGs) are an important risk factor for the development of coronary heart disease (CHD) and in acute pancreatitis. Angiopoietin-like proteins 3 (ANGPTL3) and 4 (ANGPTL4) are critical regulators of TG metabolism that function by inhibiting the activity of lipoprotein lipase (LPL), which is responsible for hydrolyzing triglycerides in lipoproteins into free fatty acids. Interestingly, individua...

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Literature Corpus work: cc80bf7c-f904-579b-9550-124ce898606b
DOI: 10.1101/2021.03.08.434130

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