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Article

Characterization of HIV-1 uncoating in human microglial cell lines.

Virology journal - 6 Mar 2020

Ingram Zachary, Taylor Melanie, Okland Glister, Martin Richard, Hulme Amy E

Abstract excerpt

BACKGROUND: After viral fusion with the cell membrane, the conical capsid of HIV-1 disassembles by a process called uncoating. Previously we have utilized the CsA washout assay, in which TRIM-CypA mediated restriction of viral replication is used to detect the state of the viral capsid, to study the kinetics of HIV-1 uncoating in owl monkey kidney (OMK) and HeLa cells. Here we have extended this analysis to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32143686
DOI: 10.1186/s12985-020-01301-5
PMCID: PMC7060623

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Related research

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Characterization of HIV-1 uncoating in human microglial cell lines.PMID 32143686Read ↗

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Revisiting HIV-1 uncoatingSemantic proximity Read ↗

HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription.Semantic proximity Read ↗

The Role of Capsid in HIV-1 Nuclear EntrySemantic proximity Read ↗

Early cytoplasmic uncoating is associated with infectivity of HIV-1Semantic proximity Read ↗

Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection.Semantic proximity Read ↗

HIV-1 Uncoating Is Facilitated by Dynein and Kinesin 1Semantic proximity Read ↗

Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1.Semantic proximity Read ↗

Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral CoreSemantic proximity Read ↗

PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced UncoatingSemantic proximity Read ↗

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