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Article

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.

Genes & development - 1 Apr 2020

Harr Jennifer C, Schmid Christoph D, Muñoz-Jiménez Celia, Romero-Bueno Raquel, Kalck Véronique, Gonzalez-Sandoval Adriana, Hauer Michael H, Padeken Jan, Askjaer Peter, Mattout Anna, Gasser Susan M

Abstract excerpt

Mutations in the nuclear structural protein lamin A produce rare, tissue-specific diseases called laminopathies. The introduction of a human Emery-Dreifuss muscular dystrophy (EDMD)-inducing mutation into the C. elegans lamin (LMN-Y59C), recapitulates many muscular dystrophy phenotypes, and correlates with hyper-sequestration of a heterochromatic array at the nuclear periphery in muscle cells. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32139421
DOI: 10.1101/gad.332213.119
PMCID: PMC7111258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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