Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.

Molecular biology of the cell - 1 Feb 2012

Barkan Rachel, Zahand Adam J, Sharabi Kfir, Lamm Ayelet T, Feinstein Naomi, Haithcock Erin, Wilson Katherine L, Liu Jun, Gruenbaum Yosef

Abstract excerpt

Emerin and LEM2 are ubiquitous inner nuclear membrane proteins conserved from humans to Caenorhabditis elegans. Loss of human emerin causes Emery-Dreifuss muscular dystrophy (EDMD). To test the roles of emerin and LEM2 in somatic cells, we used null alleles of both genes to generate C. elegans animals that were either hypomorphic (LEM-2-null and heterozygous for Ce-emerin) or null for both proteins. Single-null...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Longevity
Share to Mesoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitosis

Share to Muscle Contraction

Share to Muscle, Smooth

Share to Muscular Dystrophy, Emery-Dreifuss

Share to Nuclear Envelope

Share to Sarcomeres

Source

Open in PubMed Open full text

Identifiers

PMID: 22171324
DOI: 10.1091/mbc.E11-06-0505
PMCID: PMC3279384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.PMID 22171324Read ↗

The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans.Semantic proximity Read ↗

MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.Semantic proximity Read ↗

Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.Semantic proximity Read ↗

Emerin in health and disease.Semantic proximity Read ↗

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.Semantic proximity Read ↗

Lem2 is essential for cardiac development by maintaining nuclear integrity.Semantic proximity Read ↗

Emery-Dreifuss muscular dystrophy at the nuclear envelope: 10 years on.Semantic proximity Read ↗

Multiple and surprising new functions for emerin, a nuclear membrane protein.Semantic proximity Read ↗

Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membraneSemantic proximity Read ↗

Essential roles of LEM-domain protein MAN1 during organogenesis in Xenopus laevis and overlapping functions of emerin.Semantic proximity Read ↗

LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy.Semantic proximity Read ↗

Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery-Dreifuss muscular dystrophy caused by an LMNA gene mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.