Article

Muscular dystrophy-associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis controlling cytoplasmic macromolecular crowding

2025-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Emery-Dreifuss muscular dystrophy (EDMD) arises from mutations in nuclear lamins or emerin. Current pathological models emphasize defects in nuclear mechanics and transcription regulation. Yet these models do not fully explain the complexity of EDMD or other laminopathies. Here, we uncover an emerging pathway linking nuclear lamina defects to the reorganization of cytoplasmic biophysics, reveali...

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Literature Corpus work: 4d5a3751-053c-51c1-9204-713c14e23a50
DOI: 10.1101/2025.09.22.677926

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