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Article

Laminopathies disrupt epigenomic developmental programs and cell fate.

Science translational medicine - 20 Apr 2016

Perovanovic Jelena, Dell'Orso Stefania, Gnochi Viola F, Jaiswal Jyoti K, Sartorelli Vittorio, Vigouroux Corinne, Mamchaoui Kamel, Mouly Vincent, Bonne Gisèle, Hoffman Eric P

Abstract excerpt

The nuclear envelope protein lamin A is encoded by thelamin A/C(LMNA) gene, which can contain missense mutations that cause Emery-Dreifuss muscular dystrophy (EDMD) (p.R453W). We fused mutated forms of the lamin A protein to bacterial DNA adenine methyltransferase (Dam) to define euchromatic-heterochromatin (epigenomic) transitions at the nuclear envelope during myogenesis (using DamID-seq). Lamin A missense...

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Share to Chromatin Immunoprecipitation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophy, Emery-Dreifuss

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Share to Satellite Cells, Skeletal Muscle

Share to Site-Specific DNA-Methyltransferase (Adenine-Specific)

Share to SOXB1 Transcription Factors

Source

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Identifiers

PMID: 27099177
DOI: 10.1126/scitranslmed.aad4991
PMCID: PMC4939618

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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