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Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia

13 Nov 2017

Abstract excerpt

Abstract Mixed lineage leukemia (MLL) gene rearrangements characterize approximately 70% of infant and 10% of adult and therapy-related leukemia. Conventional clinical diagnostics, including cytogenetics and fluorescence in situ hybridization (FISH) fail to detect MLL translocation partner genes (TPG) in many patients. Long-distance inverse (LDI)-PCR, the “gold standard” technique that is used to characterize MLL...

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PMID: 29133595
DOI: 10.1158/1541-7786.mcr-17-0569

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