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Article

Expanding the spectrum of genetic causes of DNA-specific exonuclease TREX1 variants in thrombotic microangiopathy.

Kidney international - 1 Aug 2025

Song Zhuo-Ran, Liu Zhi-Ying, Li Meng-Shi, Li Yang, Li Jing-Yi, Lv Ji-Cheng, Zhang Hong, Zhou Xu-Jie

Abstract excerpt

INTRODUCTION: Thrombotic microangiopathy (TMA) is a complex condition involving endothelial damage and microvascular thrombi. The International Society of Nephrology's aHUS International Forum identified genetic variants as crucial for tailored therapies like plasma exchange and anti-complement therapy. Recent studies suggested that new pathogenic genes beyond complement and coagulation pathways contribute to TMA...

Read the complete abstract on PubMed

Topics

Humans
Exodeoxyribonucleases
Phosphoproteins
Thrombotic Microangiopathies
Retrospective Studies
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Glomerulonephritis, IGA

Female

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Middle Aged

Adult

Genetic Predisposition to Disease

Source

Identifiers

PMID: 40383229
DOI: 10.1016/j.kint.2025.04.014

Genes

TREX1
C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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