Article
The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy.
Blood - 25 Feb 2016
Jodele Sonata, Zhang Kejian, Zou Fanggeng, Laskin Benjamin, Dandoy Christopher E, Myers Kasiani C, Lane Adam, Meller Jaroslav, Medvedovic Mario, Chen Jenny, Davies Stella M
Abstract excerpt
Transplant-associated thrombotic microangiopathy (TA-TMA) occurs frequently after hematopoietic stem cell transplantation (HSCT) and can lead to significant morbidity and mortality. There are no data addressing individual susceptibility to TA-TMA. We performed a hypothesis-driven analysis of 17 candidate genes known to play a role in complement activation as part of a prospective study of TMA in HSCT recipients....
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