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Article

The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection.

Scientific reports - 16 Nov 2016

Spagnuolo Lorenza, De Simone Maura, Lorè Nicola Ivan, De Fino Ida, Basso Veronica, Mondino Anna, Cigana Cristina, Bragonzi Alessandra

Abstract excerpt

Patients with P. aeruginosa airways infection show markedly variable clinical phenotypes likely influenced by genetic backgrounds. Here, we investigated the cellular events involved in resistance and susceptibility to P. aeruginosa chronic infection using genetically distinct inbred mouse strains. As for patients, different murine genotypes revealed variable susceptibility to infection. When directly compared,...

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Identifiers

PMID: 27848994
DOI: 10.1038/srep36924
PMCID: PMC5111113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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