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Article

Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease

3 Mar 2020

Abstract excerpt

Significance Statement Cytosine methylation plays a key role in determining cell fate and response to stimuli. Using mice with kidney-specific deletion of genes encoding de novo DNA methyltransferases Dnmt3a and Dnmt3b, the authors showed that these genes are responsible for methylation of gene regulatory regions that act as enhancers during kidney development but are then decommissioned in adult mice. Although...

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Share to Epigenetics and DNA Methylation
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PMID: 32127410
DOI: 10.1681/asn.2019080797

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