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Article

The role of multidrug resistance-1 (MDR1) variants in response to fexofenadine among Jordanians.

International journal of clinical pharmacology and therapeutics - 1 Nov 2013

Alzoubi Karem H, Khabour Omar F, Al-Azzam Sayer I, Mayyas Fadia

Abstract excerpt

OBJECTIVE: The MDR1 gene encodes for P-glycoprotein (P-gp), which is an efflux transporter at the cell membrane. The P-gp has wide substrate specificity for multiple medications, including the antiallergic drug fexofenadine. In this study, we investigated the possible association between three common MDR1 gene polymorphisms (G2677T, C3435T, and C1236T), and the anti-allergic effect of fexofenadine among...

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PMID: 24040855
DOI: 10.5414/CP201968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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